Site: The McLean Hospital Corporation
Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
Summary
The Research Data Analyst will work under the direction of the Principal Investigator to support collaborative research integrating genomic and multi-omic data with clinical and electronic health record (EHR) data. The analyst will contribute to projects investigating the genetic, epigenetic, and downstream molecular basis of psychiatric and related complex traits.
Does this position require Patient Care?
No
Essential Functions
-Perform statistical analyses of genomic and molecular data, including polygenic risk score (PRS) analyses and association testing.
-Integrate genetic, transcriptomic, methylomic, clinical, and EHR phenotype data to investigate relationships between molecular variation and clinical outcomes.
-Analyze high-dimensional transcriptomic and DNA methylation datasets.
-Train genetically regulated gene expression (GReX) models and conduct transcriptome-wide association studies (TWAS).
-Perform differential expression and association analyses using statistical frameworks such as limma and related R/Bioconductor tools.
-Organize, curate, and analyze clinical and EHR-derived phenotype data, including data collection, harmonization, quality control, and phenotype definition.
-Develop and maintain reproducible analysis pipelines in R and/or Python.
-Conduct data quality control, visualization, statistical modeling, and interpretation of results.
-Organize, document, and maintain research datasets and analysis outputs to facilitate reproducibility and collaboration.
-Work closely with investigators on study design, analysis, interpretation, and preparation of results for presentations and manuscripts.
Education
Bachelor’s or Master’s degree in bioinformatics, biostatistics, computational biology, data science, statistics, genetics/genomics, or a related quantitative field required.
Can this role accept experience in lieu of a degree?
Yes
Experience
Experience attained through education or 0–1 year of relevant research or data-analysis experience required. Academic research, internships, or coursework involving statistical analysis or biomedical data may satisfy this requirement.